Interactive worksheets · 6 classes · 6 hours

mRNA vaccines: from learner to teacher

Understand the principle through videos, design a vaccine yourself, shrink into a nanoman and travel through the cell, then become a KOICA volunteer in a poor village who builds an mRNA vaccine game and demonstrates it to friends. Your answers save automatically in this browser, and the 💾 Save button keeps them in a file. Answers are shared with the Korean version.

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Class 1 60 min

Understanding how mRNA vaccines work, through videos

mRNA is a "protein blueprint note" sent to the cell. Follow the six steps (design → packaging → cell entry → translation → immune training → natural breakdown) through short videos, and write one answer after each. Reference: theory slides (PDF, Korean)

Goal 1State the flow DNA → mRNA → protein
Goal 2Explain why the LNP is needed and how it escapes the endosome
Goal 3Answer "mRNA changes your DNA" with science

0mRNA technology on one page 5 min

First read this poster slowly for two minutes. All of today's class is on this one page. Left: the structure of mRNA; middle: the journey inside the cell; right: the six steps. Click the image to open it full size.

mRNA technology: programming cells to make proteins — overview poster
mRNA technology: programming cells to make proteins — one platform, many instructions (vaccines · cancer immunotherapy · protein replacement · gene-editing delivery)
Read the posterFrom "mRNA STRUCTURE" on the left, copy the part names in order from the 5′ end to the 3′ end.
Which of the six steps on the right contains the words "the mRNA does not enter the nucleus or alter DNA"?
Read the posterWrite the four uses listed under "ONE PLATFORM, MANY INSTRUCTIONS" at the bottom, and mark which one the game Prince of mRNA belongs to.

1Why learn this 5 min

In 2020, humanity obtained a new kind of vaccine in a single year. Yet many people were afraid to take it. "It changes my DNA." "It was made too fast to be safe." "Something stays in my body." The same stories went around in Tanzania and in Korea. The root of the fear was mostly not knowing the principle. Today's goal is to understand that principle well enough to explain it to a friend.

Warm-upWrite down one thing you have heard about mRNA vaccines (a rumour, news, something a family member said). You do not need to know yet whether it is true.

2What a cell is made of: the four biomolecules 5 min

No biology or chemistry background needed. Only four kinds of molecule matter for understanding the vaccine. As the figure on the left shows, functional groups (–OH, –COOH, –NH₂, –PO₄ …) attached to a carbon skeleton give four large molecules, and chemical structure creates biological function.

Chemical structure to biological function — carbohydrates, proteins, nucleic acids, lipids
From chemical structure to biological function: carbohydrates · proteins · nucleic acids · lipids (theory deck p. 5, figure: biologynotesonline.com)
1Nucleic acids (DNA · RNA)Information. Nucleotides link into a chain whose base sequence stores the message.Today's hero: the mRNA itself
2ProteinsWorkers. Chains of amino acids fold into enzymes, receptors and antibodies.The "antigen" the vaccine makes the cell build
3LipidsMembranes. A phospholipid bilayer builds a wall between water and water.The LNP wrapping around the mRNA
4CarbohydratesEnergy and structure. Sugars join into chains and branches.Tags on the cell surface · energy

Two of them are today's main characters. Nucleic acid: the mRNA itself. Lipid: the wrapping that carries the mRNA to the cell. And the product is a protein, the antigen. Every scene that follows is the work of these three molecules.

Q0. The LNP that wraps the mRNA and carries it to the cell is made of which of the four biomolecules?
ConnectPair each of the four biomolecules with its role in the mRNA vaccine, one line each. (nucleic acid = ?, protein = ?, lipid = ?, carbohydrate = ?)

3The central dogma: from blueprint to protein 10 min

What the nucleus does24 s · DNA is the original book in the nucleus

The nucleus keeps the original (DNA) and copies only the pages it needs as mRNA, which leaves the nucleus.

Ribosome translation animation10 s · the factory that reads the note

The ribosome reads one codon (three bases) at a time while tRNA brings the matching amino acid and links it on.

DNAmRNARibosomeProtein
The original book in the nucleusA note copying only the needed page (transcription)The factory that reads the note (translation)The finished worker · the antigen
  • Key 1 mRNA is a temporary note. It is broken down and recycled within days.
  • Key 2 mRNA does not enter the nucleus. It is read only in the cytoplasm, outside the nucleus.
  • Key 3 Information flows DNA → RNA → protein. Vaccine mRNA does not change DNA.
Q1. Where is vaccine mRNA read and turned into protein?

4How an mRNA vaccine works, at a glance 10 min

The principle of the mRNA vaccine30 s · send only the blueprint

Instead of the virus, only the blueprint of the antigen protein is sent. Our own cells make the antigen and the immune system memorises its face.

Dendritic cells and T-cell training1 min 57 s · from packaging to immune memory

LNP → dendritic cell → antigen presentation → T- and B-cell training → memory. All six steps in one video (Korean narration).

After watchingIn one sentence, what is the biggest difference between traditional vaccines (attenuated or inactivated) and an mRNA vaccine? Hint: what is put into the body?
After watchingWrite the six steps from the second video in order. (design → … → natural breakdown)

5Packaging: the lipid nanoparticle (LNP) 10 min

Structure of the LNP15 s · four lipids

Ionizable lipid · phospholipid · cholesterol · PEG-lipid. Naked mRNA is cut by RNases in the body within minutes.

Why the ionizable lipid is special2 min 54 s · its charge changes with pH

At pH 4 it is positively charged and holds the mRNA; in blood (pH 7.4) it is neutral; in the acidic endosome it turns positive again, breaks the membrane and gets out.

Q2. Why does the LNP release its mRNA only inside the endosome?

6Cell entry → translation → immune training 15 min

mRNA release: endosomal escape30 s · success rate 1–2%

Endocytosis → acidification (pH 7.4 → 4–5) → membrane disruption → escape. Too late and the lysosome digests everything.

Macrophage vs dendritic cell1 min 4 s · the sentinels of immunity

The dendritic cell samples → senses → migrates → presents. It is the teacher that shows the antigen to T cells.

A T cell wakes up only with three signals

Signal 1peptide-MHC ↔ TCR: "is this the right enemy?"
Signal 2CD80/86 ↔ CD28 co-stimulation: "is it dangerous?"
Signal 3cytokines: "what kind of T cell should I become?"

Why your arm hurts and you feel feverish after the shot: it is the sign that the immune system is training. Lymph nodes swell because one T cell is multiplying into thousands (clonal expansion).

Q3. What happens if the dendritic cell shows the T cell only the antigen (signal 1)?

7Myths and facts: true or not? 7 min

Decide first whether each statement is true, then check. The scientific fact appears with the answer.

"mRNA changes my DNA"
"It was made too fast to be tested"
"Spike protein builds up in the body"
"Immunity from infection and immunity from vaccination produce the same memory cells"

8Wrap-up: three sentences 3 min

Wrap-upGo back to the story you wrote in the warm-up and answer it with one sentence of today's science.
Wrap-upToday in three sentences. ① mRNA is ___. ② Packaging → entry → translation → memory: ___. ③ DNA does not change, because ___.
Class 2 60 min

Designing an mRNA vaccine: DNA sequence → find the mutation → design the mRNA → synthesis

A personalised cancer vaccine is made in four steps: read the patient's tumour DNA, find mutations (neoantigens) that normal cells lack, write them into a blueprint (mRNA), then synthesise it in a test tube and pack it into LNPs. It is the very road Paul walked for Rosie in Coding for Rosie. Reference: theory PDF pages 19, 23, 24; practice PDF page 8 (the "ribosome slot machine" example); novel chapters 6–8 (Korean).

Goal 1Find a mutation by comparing normal and tumour DNA
Goal 2Use the codon table to read the amino acid the mutation changed (the neoantigen)
Goal 3Design the seven mRNA parts in 5′→3′ order and explain synthesis

1DNA sequencing data: inside 200 gigabytes 10 min

A sequencer reads the DNA of tumour tissue and of normal tissue (blood) in millions of fragments and writes them to files. Paul received four files for Rosie (tumour and normal, two each), 200 gigabytes in all. Software aligns both sequences to the reference genome and looks for differences present only in the tumour (variant calling, for example with Mutect2). Paul got 4,847 candidates; choosing the ones the immune system could recognise was the next task.

ThinkWhy must the DNA of normal tissue (blood) be read too, and not just the tumour DNA? Recall the novel's chapter 6, "Why two were read".

2Find the mutated gene yourself 15 min

Below is the beginning of the human KRAS gene (codons 1–18). The top row was read from normal cells, the bottom row from tumour cells. Click the codon that differs in the tumour row.

Normal (blood)
Tumour — click the changed codon

Read it with the codon table: three bases = one amino acid

When a DNA codon is copied into mRNA, T becomes U. Use the small (partial) codon table below.

mRNA codonAmino acidmRNA codonAmino acid
GGU · GGC · GGA · GGGGlycine (Gly, G)GAU · GACAspartate (Asp, D)
GUU · GUC · GUA · GUGValine (Val, V)GCU · GCC · GCA · GCGAlanine (Ala, A)
AUGMethionine (Met, M) · startUAA · UAG · UGAstop

KRAS G12D really is one of the most common mutations in pancreatic and colorectal cancer. When the short peptide containing the mutated position, VVVGADGVGK, is displayed on the tumour cell's MHC, it becomes a "neoantigen" that normal cells do not have. This is the "enemy's face" the vaccine will teach.

Q1. Among 4,847 candidates, which mutation makes a good vaccine target?

3Design the mRNA: seven parts, 5′→3′ 15 min

The blueprint of the neoantigen peptide (the ORF) alone will not be read by the cell. Without a cap and a tail, the cell treats it as an intruder and degrades it at once. Click the parts in 5′ → 3′ order to assemble the mRNA.

5′
PartRoleIn vaccine design
5′ capprotective hat · handle for the ribosomeno cap → immediate degradation
5′ UTRintroduction (not translated)a stable UTR borrowed from the globin gene
AUG + signal peptidestart codon and "delivery address"routes the antigen into the MHC pathway
ORF (antigen)coding sequence = antigen blueprintseveral neoantigens joined together
stop codonUAA · UAG · UGAwithout it the ribosome cannot stop
3′ UTRclosing words · lifetime controla stable UTR extends the lifetime
poly(A) tailAAAA… stabilitywhen the tail wears down, degradation begins

One more thing: uridine (U) is swapped for a modified nucleoside (pseudouridine, m1Ψ) so the cell's RNA sensors (TRIM25 and others) do not treat the mRNA as an intruder. The 2023 Nobel Prize in Physiology or Medicine (Karikó and Weissman) was awarded for exactly this discovery.

DesignInstead of codons 1–18 as they are, the ORF is built by joining several neoantigen peptides. Write a design memo for our patient's ORF, including the mutation you found in step 2.

4Synthesising the vaccine: in-vitro transcription and LNP packaging 15 min

The designed sequence is made into a plasmid DNA template, and in a test tube RNA polymerase synthesises the mRNA in bulk (in-vitro transcription, IVT). No cells or viruses need to be cultured. After purification and quality control, the mRNA meets the lipids in a microfluidic mixer and becomes LNPs. Click the steps in order.

Structure of the LNP (review)15 s

When the four lipids dissolved in ethanol meet the mRNA in pH 4 buffer inside the mixer, the positively charged ionizable lipid grabs the mRNA and the whole thing self-assembles into 100 nm particles.

Kinds of endocytosis1 min 30 s · preview of the next class

How the finished LNP gets into a cell. In class 3 you will go in yourself as the nanoman.

Q2. In the microfluidic mixer, what flow ratio and speed are used for buffer (mRNA) and ethanol (lipids)?
Q3. Why must the buffer holding the mRNA be pH 4 (acidic)?

5Wrap-up 5 min

Wrap-upFrom "tumour DNA file" to "LNP in the syringe": explain today's four steps in one sentence each. It is the same order Paul followed for Rosie.
Class 3 60 min

Become the nanoman: carrying the mRNA vaccine into the cell

You are the nanoman, shrunk to 100 nanometres. On your back you carry the mRNA vaccine wrapped in an LNP. From the needle to the tumour you will pass fifteen gates. At each gate, read the short story, answer the choice question, and write one or two sentences in your first-person travel log. It is the same road as chapters 4–6 of the game Prince of mRNA, scenes 4–7 of the play, and chapter 13, "Injection", of the novel.

Goal 1Tell, in order, how mRNA becomes antigen and reaches MHC inside the dendritic cell
Goal 2Explain how T cells find their match, get armed and multiply in the lymph node
Goal 3Explain the immune checkpoint (PD-1/PD-L1) and checkpoint inhibitors
How to write the log — "I am now in ___. Around me is ___. I must ___, because ___." Use at least one science term. Tick ✔ at each gate to mark it on the ladder.

★Before you leave: the nanoman's vehicle, the dendritic cell at a glance 8 min

From gate 1 to gate 11 the nanoman rides a single dendritic cell. Capture → migrate → present → activate: this cell's day is the first half of the vaccine. Skim the infographic for two minutes, then do the "poster hunt". Click the image to open it full size.

Dendritic cell infographic — the antigen-presenting sentinel linking innate detection to adaptive immunity
Dendritic cells: the antigen-presenting sentinels that link innate detection → adaptive immunity

🔍 Poster hunt: tick each one you find

🧭 Match poster sections to the nanoman's gates

Choose at which gate of the journey below each poster scene happens.

Looking at poster section ⑥ and the cross-presentation box beside it: what is the most direct reason the mRNA vaccine's antigen reaches MHC class I and wakes CD8⁺ killer T cells?
In my wordsPick three of the seven QUICK FACTS on the poster and rewrite them in your own words from the nanoman's point of view. (e.g. "The cell I ride matures when it senses danger, and then…")
Muscle tissue · 0 s after injection

Landing: from the needle tip into the tissue

Together with 0.5 millilitres of liquid I drop into the gap between muscle fibres (the interstitium). Around me is body fluid full of RNases. The mRNA on my back is still safe thanks to the LNP shell. In the distance a huge cell with outstretched tentacles comes into view: a dendritic cell.
Why is the nanoman safe here?
Log 1
Dendritic cell surface · minutes later

Swallowed: endocytosis

The dendritic cell's membrane wraps around me and pulls me inside. The membrane pinches off into a pouch. I am now trapped inside an endosome. Beyond the wall, proton pumps start to run. It is getting more and more acidic around me.
The dendritic cell, scout of the immune system34 s · eats and presents
Log 2
Inside the endosome · 30–45 min

Endosomal escape: watching the pH gauge

pH 7.4 → 6.6 → 6.0 → 5.2 … As it turns acidic, the LNP's ionizable lipid becomes positively charged and clings to the negatively charged endosome membrane. The membrane wobbles. Now! Too late and the lysosome fuses in and digests everything. Only one or two in a hundred make it.
pH 7.4 neutral6.65.2 escape window4.0 lysosome
When should you press the escape button?
Endosomal escape → ribosome (virus analogy video)1 min 34 s · viruses use the same door

A virus escaping the endosome and using the ribosome. The mRNA vaccine borrows only this "trick" from viruses and has no ability to replicate.

Log 3
Cytoplasm

Running from the nucleases

I am out in the cytoplasm. The LNP has peeled away and the mRNA is naked now. In the dark, exonucleases rush in to nibble it from the tail, and sensors like TRIM25 try to tag it as "foreign RNA!". But every U in my mRNA has been swapped for m1Ψ, so it slips out of the sensors' grip, and I must reach the ribosome before the poly(A) tail wears away.
Why can TRIM25 not catch the vaccine mRNA?
Log 4
The ribosome workshop

Reaching the ribosome: synthesising the antigen peptide

The 5′ cap calls the small ribosomal subunit (40S). When it finds AUG, the large subunit (60S) closes over it. For each codon a tRNA brings one amino acid and links it on. Thanks to the signal peptide the chain enters the endoplasmic reticulum, folds, and passes quality control. At the stop codon it is complete. The neoantigen protein is born.
Ribosome → endoplasmic reticulum → Golgi58 s · the road a protein travels after it is made
Log 5Describe the ribosome reading your mRNA. Use both words: "codon" and "amino acid".
ER → cell surface

Posted on MHC: hanging out the enemy's face

The protein is chopped by the proteasome into pieces of 8–10 amino acids, passes through the TAP pump, and is slotted into MHC I inside the ER. MHC-peptide rises to the cell surface and is displayed like a billboard. At the same time the dendritic cell senses a danger signal and matures: co-stimulatory molecules (CD80/86) increase and CCR7 antennae sprout.
What displays fragments of antigen made inside the cell?
Log 6
Tissue → lymphatic vessel → lymph node · hours to a day

The long road to the lymph node

The matured dendritic cell carries me and moves. Smelling the CCL19/CCL21 given off by the lymph node through its CCR7, it heads toward the stronger scent, and stronger still. It climbs into a lymphatic vessel and rides the flow to the node's entrance. Game chapter 5, "chemokine navigation", is this very road.
Riding the dendritic cell to the lymph node (virus analogy video)1 min 26 s
Log 7Explain in your log what it means to "follow a concentration gradient".
Lymph node, T-cell zone

Meeting the herd of young T cells

Inside the lymph node millions of naive (young) T cells throng. Each holds a single differently shaped TCR key and waits its whole life for its own lock. One T cell recognises only one kind of antigen.
Kinds of lymphocytes: T cells and B cells1 min 19 s
A T cell detects only one antigen33 s
Log 8
The immune synapse

Finding the match: key and lock

The dendritic cell weaves among the T cells, showing its MHC-peptide. After thousands of brushes, one T cell's TCR clicks into place. An LFA-1 / ICAM-1 ring forms between them and an immune synapse is built. Signal 1 is on.
Log 9Write why so many T cells have to be met before the right match is found.
Immune synapse · signals 2 and 3

Arming the young T cell into a soldier

Signal 1 alone puts the T cell to sleep. The dendritic cell presses CD80/86 against CD28 to say "this is dangerous" (signal 2) and sprays cytokines commanding "become a killer T cell" (signal 3). The young T cell opens its eyes. Now it is a soldier (cytotoxic T cell).
What does a T cell need to become a soldier?
Log 10
Lymph node · several days

Clonal expansion: one becomes hundreds of thousands

The awakened T cell divides. One becomes two, two become four… Within days the soldiers carrying the same key number in the hundreds of thousands. The lymph node swells. This is why your armpit felt sore after the shot. Some remain as memory T cells and wait for years.
Log 11
Bloodstream → tumour microenvironment

Charging at the cancer cells

The soldiers leave the lymph node and race through the blood vessels. Near the tumour they squeeze out through the vessel wall (extravasation) and enter the tumour. But the tumour is a fortress. Regulatory T cells (Tregs) whisper "do not attack", fibroblasts (CAFs) build collagen walls, and hypoxic zones short of oxygen exhaust the soldiers. Game chapter 6, "T-cell army", is this road.
Immune cells breaking through the vessel wall54 s
How cancer cells build blood vessels10 s · the tumour builds its own supply lines
Log 12
Inside the tumour · cancer cell surface

The immune checkpoint: the cancer cell's shield

A soldier reads the neoantigen on the cancer cell's MHC I. Yes, this is the enemy. But the cancer cell holds out PD-L1 and presses it against the soldier's PD-1. "I am on your side. Stop." The soldier's grip loosens. This is the checkpoint by which cancer cells fool the immune system.
What happens when PD-L1 binds PD-1?
Log 13
Inside the tumour · after the checkpoint inhibitor

Breaking through: help from the anti-PD-1 antibody

Then, riding the bloodstream, the anti-PD-1 antibody (immune checkpoint inhibitor) arrives. The antibody covers the soldier's PD-1 first. The cancer cell's PD-L1 has nothing to touch. The brake is released. The soldier raises its hand again.
Log 14Write why the vaccine (teaching the antigen) and the checkpoint inhibitor (releasing the brake) have to be used together.
Inside the tumour · the cytotoxic immune synapse

Killing the cancer cell: a quiet death

The soldier clamps onto the cancer cell, punches holes with perforin and pours in granzyme B. Inside, caspases switch on in a chain reaction and the cancer cell folds itself into pieces (apoptosis). It dies quietly, without bursting. The normal cell next door carries no neoantigen, so it is left alone. New antigens leak from the dead cancer cell and other T cells learn them too (epitope spreading). Spring returns.
Real footage of a T cell attacking a cancer cell15 s · the real thing under a microscope
Why does the soldier leave normal cells alone?
Log 15The last entry of the journey. As the nanoman, which gate was the most dangerous, and why?

★Wrap-up: draw the map of the journey

Wrap-upSummarise the fifteen gates as a one-line map. Arrows are fine. It will become the skeleton of the game you build next class.
Class 4 60 min

Mission: you are a KOICA volunteer

Reference: practice slides (PDF, Korean) pages 5–14; example apps ONCO-PURGE and Ribosome Slot Machine.

Mission briefing

You have arrived as a KOICA (Korea International Cooperation Agency) volunteer in a poor village where the power often fails. A rumour that "mRNA vaccines are dangerous" is going around, and children are not being vaccinated. Mission: teach the village youth how mRNA vaccines work.

Means: build an mRNA vaccine education game that runs on a single phone and use it in class. To do that, first play the game made by Sharing and Technologies and learn what works.

Accept the missionImagine three reasons the villagers might be afraid, and write one line each on how a game could answer that fear.

1Reconnaissance: play Prince of mRNA 25 min

  1. Open prince.aiedus.org (phone or laptop, nothing to install)
  2. Enter your name and class code → live ranking on the classroom screen
  3. Move: arrow keys/WASD · jump: space · interact: E · tutorial: ?
  4. You may start from chapter 3 (Chapter Select). First to clear the tumour wins. Press F3 for English.
🎮 Open the game

Recon log: tick the chapters you cleared

Recon analysisThe most fun mini-game and why: which "rule" made you learn which "science" with your hands?
Recon analysisThe hardest or least explained part. Where would a village teenager get stuck?

2My own game scenario: a one-page plan 20 min

Start small, go deep. A game that handles one or two science steps accurately beats one that skims all six. The format may be a game, a play or a novel.

Science stepAs a scene or ruleEnemy · danger
① Design and assemblyA puzzle putting the 7 parts in 5′→3′ orderWrong order and the ribosome cannot read it
② LNP packagingMatching the ratio of 4 lipids, running the mixerRNases cut naked mRNA
③ Cell entry and escapeTiming on the pH gaugeToo late: lysosome; too early: failure
④ TranslationMatching codons to amino acidsA time limit as the poly(A) tail wears down
⑤ Antigen presentation and T cellsMatching key (antigen) to lock (TCR), three signalsWith only one signal the T cell falls asleep
⑥ Attacking the tumourTelling cancer cells from normal cells and attackingPD-L1 shield → break it with the antibody

3Build your first game in Google AI Studio 15 min

  1. aistudio.google.com: sign in with a Google account (free)
  2. Left menu Build → the app description box
  3. Copy the auto-generated prompt below, paste it in and send
  4. Play it right away in the preview on the right → fix it by chatting ("the score does not go up", "make the buttons bigger")
  5. Download → index.html (or a ZIP) = your game. File name: class_name_title.html

Alternative: stivibe.iotok.org/create works the same way.

Auto-generated prompt: fill in the plan above and it is assembled here in the six-line template

Fill in the plan above and the prompt will appear here.

The six lines of a good prompt: ① role and purpose ② format (one HTML file, language, phone and PC, no external libraries) ③ screen ④ rules and state ⑤ science (write exact facts yourself, never invent) ⑥ finish (help, restart, a science summary on the result screen)

First resultDid the game from your first prompt run? What went well and what was wrong (science, behaviour, screen)? Three things to fix next class.
Class 5 60 min

Improving the game: working, correct, fun, then pretty

The order matters. ① Does it run? → ② Is the science right? → ③ Is it fun? → ④ Does it look good? AI makes plausible mistakes. You are the reviewer. Reference: practice PDF pages 15–21.

0–10 minZero errors (F12 console)
10–35 minCheck the 7-line science checklist · fix the rules
35–60 min2–3 Gemini images · test with a friend

1Fix log: one thing at a time 25 min

Bad request: "the score does not go up" / "make it more fun"
Good request: "The score should rise by 100 on a successful escape but stays at 0. Fix it." / "When I fail, show one line explaining why, with the pH value."

#Problem foundRequest sent to the AIResult
1
2
3

Common blockers

SymptomFix
The screen is blankCopy the red error from the F12 console: "fix this error"
Images do not showCheck file name, extension and capitalisation, and that it sits in the same folder as index.html
Buttons are tiny on the phone"Make the buttons finger-sized (at least 48 px) and support touch events"
No soundBrowsers allow sound only after the first tap → "play after the start button"
The AI ignores my requestNew chat → paste the current file → ask for one thing only

2Science accuracy checklist: a wrong app spreads wrong knowledge 10 min

Open your game and compare line by line. Lines that do not apply may be ticked as "not applicable". 40% of the mark depends on this.

ReviewWhich checklist lines did your game get wrong, and how did you fix them? (If none, write "none" and your evidence.)

3Image assets: draw with Gemini and put them in the app 15 min

  1. Add the same style sentence to every image for consistency ("bright educational cartoon style, thick outlines, simple background")
  2. Save in the same folder as index.html · <img src="lnp.png"> · tell the AI the file name
  3. If an image does not show: file name, extension, capitalisation

4Friend test: can they start within a minute without explanation? 10 min

TestYou swapped games with the next team. How long did your friend take to start without explanation, and where did they get stuck?
TestAfter finishing, you asked your friend to "say today's science in one sentence". What did they say? Did it match your intention?

Completion criteria: checklist before presenting

Class 6 60 min

Demonstrate to friends, get reviewed, and wrap up what you learned

Upload 10 min → 3-minute talk per team → peer review → wrap-up. Reference: practice PDF pages 22–26.

1Release it to the world: upload to stivibe.iotok.org 10 min

2The 3-minute talk: science 1 min · demo 1 min 30 s · what I learned 30 s 25 min

3Peer review: science is 40% 15 min

ItemPointsWhat to look forScore
Scientific accuracy40All 7 checklist lines pass · order, numbers, terms · the talk explains the principle correctly
Teaching effect20Starts within a minute unaided · afterwards you can state the principle in one sentence · science summary on the result screen
Polish20No errors · works on a phone · consistent images and style · restart and help
Presentation20Keeps to 3 minutes · a clear science minute · the demo links rules to science · answers questions
0/ 100

4What I learned: the final quiz 10 min

Questions across all six classes. Answer them all, then check your score.

1. Where is vaccine mRNA read?
2. Why is normal-tissue DNA also read when designing a cancer vaccine?
3. The correct order of mRNA parts is?
4. The principle of endosomal escape is?
5. How many signals does a naive T cell need to become a soldier?
6. What does an immune checkpoint inhibitor (anti-PD-1 antibody) do?
7. What remains in the body a few weeks after vaccination?
8. How are the COVID mRNA vaccine and a personalised cancer mRNA vaccine related?
—/ 8

5Looking back: from learner to teacher

  1. Science must be accurate to be passed on. The fear of the pandemic came from not knowing. The app we built passes on the accurate principle simply.
  2. AI is a tool. What to build, whether the science is right and whether it is fun are decided by people. A prompt is the result of thinking.
  3. You learn best by teaching. Send the link to your family and explain it. If you can explain it, you really know it.
Wrap-upLook again at the story you wrote in class 1. What would you now explain to a villager, in what order, and with which game? Five sentences.
Wrap-upPaul Conyngham walked this road for one dog, Rosie. Whose "Rosie" is your game for?
Mission reportKOICA volunteer mission report: outcome · what went best · what you would do differently in the next village.